Efficacy of Combination Therapy with Aztreonam and Arbekacin for Urinary Tract Infection Due to Multi-drug Resistant Pseudomonas aeruginosa: A Case Report

Abstract

  A 93-year-old female suffered from left endophthalmitis in a local hospital, and multi-drug resistant Pseudomonas aeruginosa (MDRP) was found in her urine culture immediately after transfer to our hospital for therapeutic surgery of the eye. After the operation, she developed urinary tract infection due to MDRP, so was treated with combination therapy of aztreonam (AZT) and arbekacin (ABK) at the same time as pull out of the Foley catheter and diuretic therapy. The AZT-ABK combination therapy resolved the infectious disease. The FIC index of combination therapy with AZT and ABK was 0.375, indicating agent synergy. We suggest that combination therapy of AZT and ABK is useful for the treatment of MDRP infection in the urinary tract.