Long-term Monitoring and Analysis for Changing of Selectivity and Consumption of Antimicrobial Drugs Estimated with AUD in Our Hospital I

Abstract

  This study evaluated the changes in antimicrobial use density (AUD) for injections at our hospital over 7 years (2001-2007), and investigated the factors affecting consumption and selectivity of antimicrobials. Consumption of glycopeptide antibiotic showed no increase or antimicrobial drugs with susceptibility to Pseudomonas aeruginosa decreased in 2002 and 2005, respectively. However, use of first generation cephalosporins increased after 2002. These changes depended on revised guidelines for use of antimicrobial drugs. This report was one of the few studies of long-term monitoring of use of antimicrobial drugs at medical institutions in Japan.