Effect of Broad Spectrum Antimicrobial Agents Use Monitoring Policy on Drug Resistance in Pseudomonas aeruginosa

Abstract

  Overuse of antimicrobial agents may lead to increased drug resistance in various strains of bacteria. Our institution started a use monitoring policy for broad spectrum antimicrobial agents. In this study, Antimicrobial use density (AUD) of carbapenem (CBPM) and fluoroquinolone (FQ) antimicrobial agents for every half year between April 1, 2007 and March 31, 2009 and the trends of resistance to IPM/CS and CPFX of Pseudomonas aeruginosa were analyzed to evaluate the use monitoring policy. The resistance rates to IPM/CS and CPFX were decreased from 29% and 20% to 21% and 15%, respectively. Mean administration days and long-term administration rates of CBPM were decreased from 7 days and 32% to 6 days and 24%, respectively, and the AUD of CBPM showed slightly decreasing trends. In contrast, the AUD of FQ showed little change. The present study indicates that the use monitoring policy was effective for reducing carbapenem antimicrobial agent use, and reduces the antimicrobial resistance of P. aeruginosa.