Prolonged Norovirus Shedding for More than Three Months in Two HIV-infected Patients: Two Case Reports

Abstract

  We report two cases of prolonged norovirus shedding for more than 3 months in severely immunocompromised HIV-infected patients. One of the patients had persistent diarrhea throughout his hospital stay and nosocomical transmission took place in the ward. Patients with leukemia, lymphoma or primary immunodeficiency, and patients taking immunosuppressive therapy have also been reported to develop chronic norovirus infection resulting in nosocomical infection. Our cases demonstrate that immunocompromised patients can suffer prolonged periods of norovirus infection for months, so we must take appropriate durations of infection control measures.