Antimicrobial Usage and Resistance Surveillance in 19 Hospitals of Hiroshima Prefecture

Abstract

  Antimicrobial agent AUD value and resistant bacterium factorability were investigated in 19 hospitals of Hiroshima prefecture from January to June, 2010. The percentile (10, 25, 50, 75, 90%) of 13 antimicrobial agents was calculated from the AUD value of each hospital, and benchmarks for antimicrobial agents in Hiroshima prefecture were established. There were some hospitals where the AUD value of MEPM and IPM/CS is high, and it is necessary to investigate whether Carbapenem agent is appropriate used in these hospitals. The relationship between AUD value of each antimicrobial agent and detection rate of resistant microbe was investigated. The detection rate of MRSA and AUD value of CMZ had a negative correlation. The detection rate of ESBL of E. coli and AUD value of CFPM tended to positive correlation, AUD values of CAZ and CTRX had no correlation. There was no correlation in the detection rate of P. aeruginosa (Carbapenem resistant) and AUD value of MEPM and IPM/CS. The relationship between antimicrobial agent AUD value and resistant microbe requires more examination because there are a lot of uncertain points. More detailed surveillance will be necessary in the future because AUD and various other factors are related to the appearance of antimicrobial resistant bacteria. The surveillance of regional cooperation concerning antimicrobial agent AUD value and resistant microbe is useful for control of the detection of antimicrobial agent resistant bacteria.