Abstract
The detection rate of extended-spectrum beta-lactamase (ESBL) producing bacteria varies in different regions, so surveillance of the detection rate of ESBL producing bacteria in each region is beneficial for infectious disease treatment and infectious disease control. We conducted a multicenter research study on measures to promote the correct use of antimicrobial agents, by examining the detection rate of ESBL producing bacteria and the antimicrobial use density (AUD) at 29 facilities in the KYUSYU–YAMAGUCHI region. The formulation planning and the adoption of a notification system for carbapenem prescription were associated with a significant reduction in the AUD of carbapenems. However, this approach resulted in significant increase in the AUD of 3rd generation cephalosporins. There was no significant difference in the detection rate of ESBL producing bacteria between regions. However, the detection rate of ESBL producing bacteria tended to be higher in Fukuoka prefecture compared to other region. There was no significant relationship between the AUD of antimicrobial agents, 4th generation cephalosporins and carbapenems, and the detection rate of ESBL producing bacteria. These results suggest that the spread of ESBL producing bacteria is connected to horizontal infection in hospitals and antimicrobial use for outpatients. Therefore, we think that combined measures should be undertaken to prevent the spread of ESBL producing bacteria.
