Monitoring Use of Antimicrobial Agents and Incidence of Drug-Resistance in the Kitakyushu Eastern Region

Abstract

 To control the spread of drug-resistant microorganisms in a local community, preventive action should be based not on action at a single health-care facility but rather should involve cooperation across facilities. We explored the association between the use of antimicrobial agents and drug resistance in the eastern region of Kitakyushu-shi. The results were compared between two groups: additional reimbursement for infection prevention regional collaboration 1 and 2. We also surveyed the incidence of multidrug-resistant Pseudomonas aeruginosa in each facility. Antimicrobial use density (AUD) was measured in terms of carbapenem use. The results showed no significant difference in antimicrobial use and resistance ratio of P. aeruginosa between the two groups. Therefore, antimicrobial use was not correlated with resistance ratio of P. aeruginosa. Based on these results, infection-control measures other than the AUD of antimicrobial agents are important in controlling the susceptibility ratio. In addition, as multidrug-resistant P. aeruginosa was found in several facilities, prevention of spread of infection through inter-regional cooperation is necessary.