2020 Volume 35 Issue 5 Pages 201-205
In Tama-Nanbu Chiiki Hospital, a pharmacist-initiated antimicrobial stewardship program was started to optimize the use of antimicrobial agents in the hospital. Previously, at 10 months after the start of the program, the therapy durations for both 4th cephem and carbapenem were shortened. However, at that time, the resistance rate of Pseudomonas aeruginosa for both agents did not markedly change. Currently, we evaluated the correlation between the resistance rate of Pseudomonas aeruginosa and above mentioned antibiotics at 3 years after intervention. Although the day of therapy (DOT) was almost the same as that at 10 months of intervention, we achieved decreased resistance of Pseudomonas aeruginosa for both antibiotics. A positive correlation was observed between 4th cephem resistance rate in Pseudomonas aeruginosa and DOT (0.90, p = 0.04).
To reduce the antimicrobial resistance rate, a longer period of intervention is recommended.
