Improvement of Antibiotic Susceptibilities of Psudomonas aeruginosa Due to Intervention of Mixing Therapy in the Ward of Hematology

Abstract

Mixing therapy involves sequential change of the first-line antibiotic administered to patients with febrile neutropenia using six different agents. Pseudomonas aeruginosa is a major hospital-acquired pathogen for patients with hematologic disorders, so the incidence of isolates of multi-drug resistant P. aeruginosa (MDRP) and the susceptibilities to antibiotics were retrospectively investigated during three periods, before and after the introduction of mixing therapy, and the last 1 year. The results showed that the isolation rate of MDRP had decreased and the susceptibilities to most antibiotics had increased. Mixing therapy may be effective for preventing the development of antibiotic resistance.