1988 Volume 47 Issue Suppl-4 Pages 120-123
In an attempt to reduce endolymphatic hydrops, Isosorbide (ISO) has been adminstered to patients with definite Meniere's disease since the beginning of the 1980s in our departments. Follow-up studies of two years or longer on 19 patients were available for analysis according to the 1985 AAO-HNS evaluation criteria.
1) Vertigo: Complete control of definite attacks was achieved in seven patients (37%), substantial control in five (26%) and limited control in four (21%).
2) Hearing loss: The three frequency pure-tone average at 500 Hz, 1 KHz and 2 KHz was utilized for the assessment of the hearing level. Hearing improved in five patients (26%), was unchanged in seven and deteriorated in seven.
3) Disability: 14 patients (74%) were improved, while five (26%) were unchanged.
These findings suggest that ISO is one of the most appropriate conservative treatment for disabling Meniere's disease.
