Immunohistochemical analysis of the lateral wall of the endolymphatic sac of the patients with Meniere's disease
4th report using PAP method
1988 Volume 47 Issue Suppl-4 Pages 31-36
Details
1988 Volume 47 Issue Suppl-4 Pages 31-36
In this series of reports, further information has substantiated the existence of immunoglobulins (IgG, IgA, IgM) in the lateral walls of endolymphatic sacs, obtained during endolymphatic sac surgery from 19 patients with Meniere's disease.
In an immunohistochemical procedure using the PAP method (peroxidase-anti-peroxidase method), IgG was recognized in the epithelium and the subepithelial layer of the endolymphatic sacs of 12 of the 19 (63 %) patients with Meniere's disease, while IgA and IgM were absent in all of the patients.
It is still impossible to determine the exact site of some active immunological reactions and the resultant products in the sac, but this finding suggests that some immunological disorders might exist in the endolymphatic space, including the sac and that they might be closely related to one of the causes of endolymphatic hydrops.
