Abstract
The elasticity of Reissner's membrane was investigated in guinea pigs with experimentally induced endolymphatic hydrops. Isosorbide, an osmotic diuretic, was administered to reduce the size of the endolymphatic space and thereby decrease pressure on the bulging Reissner's membrane. If elasticity is present, a consequent shortening of this membrane would be expected. Significant folding in the basal turn of the cochlea was observed, but careful measurement with a microscope, video camera, and computer arrangement revealed no contraction of Reissner's membrane in comparison with guinea pigs which had not received isosorbide. This indicates a lack of elasticity in the membrane following the occurrence of endolymphatic hydrops, suggesting irreversibility of the elongation process.
