Abstract
In this Paper we studied the clinical effects of long-term urea medication in patients with Meniere's disease. The subjects were 32 patients with Meniere's disease whose main symptoms were recurrent vertigo, deafness, tinnitus and aural pressuresensation.
Urea (1020 g) was given orally before breakfast twice a week at the start of the therapy, then once a week as the clinical symptoms stabilized.
The patients were followed for 12 months. In accordance with the 1972 criteria of the American Academy of Ophthalmology and Otolaryngology, 23% had class A, 61% class B, 6% class C, and 13% class D results.
Vertigo was well controlled in 90% of cases, but tinnitus persisted intermittently in many patients.
There was no appreciable side effects.
