1990 Volume 49 Issue Suppl-6 Pages 56-60
This study was designed to evaluate the effects of various agents (2.4 ml/kg 50% glycerol, 1.6 ml/kg 70 % isosorbide, 5.0 ml/kg 20 % mannitol, 5.0 ml/kg 7% 061 Meylon, 10 ml/kg 1% Cephadol) on the cochlear blood flow of guinea pigs with experimentally induced endolymphatic hydrops. The various agents were administered intravenously to the hydropic animals and to normal controls, and the cochlear blood flow was measured by a laser Doppler flowmeter.
Blood flow increases lasting several minutes were seen with all agents except Cephadol in both normal and hydropic animals. The greatest increases occurred with glycerol, followed in order by Meylon, isosorbide, and mannitol. Decreases in cochlear blood flow were seen following Cephadol administration. No differences were observed in the reaction patterns to the various agents between the normal and hydropic groups, but the degree of reaction to each agent was slightly higher in the hydropic animals than in the normals.
