Abstract
Integration mechanisms of multisensory modality in the brain are described in relation to formation of spatial orientation. Vestibular, visual and somatosensory (proprioceotive) informations are essential component in forming spatial orientation and spatial memory. The parietal association cortex is the most plausible location to convert multisensory informations into spatial orientation, while the hippocampus is one of the places to store and retrieve the built-up spatial memory (spatial orientation). Then a new hypothesis was proposed to explain the gensis of SAS (space adaptation syndromes), by considering spatial disorientation and other sensory conflicts.