Abstract
The effects of Nonylphenol (NP) on medaka, Oryzias latipes, were examined with histopathological observation. At 2 weeks of NP treatment, various lesions in the kidney appeared and became more prominent with time. These renal lesions were hyaline deposition in Bowman's space, hyaline cast, hyaline droplets in the tubular epithelium, mitosis of proximal tubular epitheliumand glomerular sclerosis with cuboidalization of Bowman's capsule. Moreover, renal tumor was observed at 24weeks. The testis-ova in medaka developed from 16 weeks of NP treatment. These various pathological changes suggested that NP has carcinogenicity rather than endocrine disrupton. Therefore, the carcinogenic effects of NP on the kidney are of a significant problem.
