Fish Pathology
Online ISSN : 1881-7335
Print ISSN : 0388-788X
ISSN-L : 0388-788X
Research Articles
Novel Exophiala Infection Involving Ulcerative Skin Lesions in Japanese Flounder Paralichthys olivaceus
Osamu KurataChutharat MunchanShinpei WadaKishio HataiYasuyuki MiyoshiYutaka Fukuda
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2008 Volume 43 Issue 1 Pages 35-44

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Abstract

A dematiaceous fungus was isolated from Japanese flounder Paralichthys olivaceus with ulceration and erosion of the skin surface. The fungus was identified as an Exophiala species, with different morphological, biological and molecular characteristics from three previously described pathogenic Exophiala species. Fungal hyphae extended laterally in the dermis, and were absent from the epidermis and musculature of the skin lesions and kidneys of the diseased fish. An inflammatory response with granuloma occurred in the dermis involving accumulations of epithelioid cells around the hyphae. The granulomas were surrounded by lymphocyte-like cells. Epidermal degeneration was observed above the inflamed dermis, suggesting that the inflammatory response caused epidermal damage. Experimental infection reproduced hyphal extension and infiltration of inflammatory cells in the dermis of the flounder, confirming the pathogenicity of the fungus.

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© 2008 The Japanese Society of Fish Pathology
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