Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1-J11

Carmelo Segovia del Castillo; Takeshi Yoshikawa; Masahito Hashimoto; Taizo Sakata

doi:10.3147/jsfp.43.65

Research Articles

Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1-J11

Carmelo Segovia del Castillo, Takeshi Yoshikawa, Masahito Hashimoto, Taizo Sakata

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Keywords: anti-bacterial substance, alkyl-quinolinol, NMR, Pseudoalteromonas

JOURNAL FREE ACCESS

2008 Volume 43 Issue 2 Pages 65-71

DOI https://doi.org/10.3147/jsfp.43.65

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Abstract

The anti-bacterial substance, AVS-03d, isolated from the culture of marine Pseudoalteromonas sp. A1-J11 was separated by HPLC with a C₁₈ column. The chemical structure of AVS-03d was identified as 2-n-pentyl-4-quinolinol (C₁₄H₁₇NO = 215.13) on the basis of mass spectrometry and NMR spectroscopy. AVS-03d showed strong inhibitory activity against Vibrio harveyi strains as compared with other quinolinol compounds, suggesting that the length of the alkyl side chain of the compound is important for anti-bacterial activity.

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