Pharmacological Characteristics of the Formalin-Killed Vaccines against Streptococcus iniae and Lactococcus garvieae in Farmed Thread-sail Filefish

Abstract

In the previous study, we evaluated the protective efficacies of the following three vaccines for the thread-sail filefish Stephanolepis cirrhifer: a commercial Streptococcus iniae vaccine, a commercial Lactococcus garvieae vaccine and a combination of these two vaccines.　In this study, we examined the three vaccines for the thread-sail filefish in terms of protective duration, protection against various heterogeneous strains of S. iniae and L. garvieae, and the effects of different water temperatures on the protection.　The vaccines induced strong protection against heterogeneous strains of S. iniae and L. garvieae, and the protection was observed for 52 weeks after the vaccination.　These vaccines also induced protective immunity when administrated at 15°C, 20°C and 25°C.