Innate Antiviral Response through Mitochondrial Antiviral Signaling Protein (MAVS) in Fish - A Review

Kurcheti Pani Prasad; Rahul Krishnan; Shyam Kokkattunivarthil Uthaman; Jeena Kezhedath; Pokanti Vinay Kumar

doi:10.3147/jsfp.59.39

Review

Innate Antiviral Response through Mitochondrial Antiviral Signaling Protein (MAVS) in Fish - A Review

Kurcheti Pani Prasad, Rahul Krishnan, Shyam Kokkattunivarthil Uthaman, Jeena Kezhedath, Pokanti Vinay Kumar

Author information

Keywords: Antiviral innate immunity, Piscine MAVS, Mitochondrial dynamics, RLR pathway, RGI-I, Signalling, PAMPs, Aquaculture

JOURNAL FREE ACCESS

2024 Volume 59 Issue 2 Pages 39-53

DOI https://doi.org/10.3147/jsfp.59.39

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Abstract

The innate antiviral response through the RIG-1-like receptor pathway is oriented towards a key regulatory molecule, mitochondrial antiviral signaling protein (MAVS). Localized to the mitochondria, MAVS coordinates the interferons (IFN) production through regulated signaling cascades. Protein-protein interaction, post-translational modifications, and mitochondrial dynamics considerably regulate MAVS signaling on the mitochondrial membrane. This review gives insight into the inevitable role of MAVS in the innate antiviral immune response of fish.

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