Time-Course Changes of the Viral Genome Copy Numbers and ELISA Antibody Titer in Coho Salmon Artificially Infected with PRV-2

Abstract

In coho salmon Oncorhynchus kisutch challenged with piscine orthoreovirus 2 (PRV-2), hematocrit values showed an immediate decline, reaching their lowest point at 40 days post-challenge (dpc), followed by a gradual recovery. ​Erythrocytic inclusion bodies were observed only between 20 and 40 dpc. ​The viral genome copy numbers peaked at 30 dpc. ​These findings suggest that the disease progressed until 40 dpc, after which recovery took place. ​The presence of ELISA antibodies against the virus was detected after 60 dpc, with a significant increase noted at 80 dpc.