Chemotherapeutical Studies on Sodium Nifurstyrenate against Streptococcus Infection in Cultured Yellowtail-I

In vitro Studies on Sensitivity and Bactericidal Effect

Abstract

The antibacterial and bactericidal activity of sodium nifurstyrenate (NFS-Na) and three therapeutic drugs were studied with Streptococcus sp.
The minimum inhibitory concentration (MIC) against Streptococcus sp. was 0.15 to 0.62 mcg/ml for NFS-Na, 0.31 to 0.62 mcg/ml for aminobenzylpenicillin, 1.2 to 2.5 mcg/ml for chioramphenicol, and 0.075 to 0.15 mcg/ml for tetracycline, respectively.
The bactericidal effect against Streptococcus sp. was observed at 5 mcg/ml of NFS-Na for 8 hrs and at 5 mcg/ml of ampicillin for 24 hrs, whereas chloramphenicol and tetracycline revealed no bactericidal effect at 10 mcg/ml for 24 hrs.