Abstract
The results of the basic and application studies with doxycycline (DOTC) were summarized as follows.
Doxycycline was stable in both substance and preparation.
It also keeps its stability in feed for yellow-tail. The half life of doxycycline was 7 days in sea-water or in sea-water and active sludge.
Doxycycline had very low toxicity against experiment animals and yellow-tail: its safety was high. It was quickly absorbed in body of experiment animals and was distributed systemically.
Doxycycline was efficacious against Streptococcosis in yellow-tail at the administration of 20-50 mg/kg of body weight. Its withdrawal period was 20 days.
