Abstract
The defensive effect of bovine lactoferrin on Cryptocaryon irritans infection of red sea bream, Pagrus major, was studied. Neither mortality nor clinical sign of white spot disease was observed in the fish orally administered with lactoferrin (40 mg/kg body weight/day) for 28 days, whereas most untreated controls died within 28 days. These facts suggest that the lactoferrin has a defensive effect on C. irritans infection of red sea bream.