Abstract
Sulfamonomethoxine has been shown to be efficacious in the treatment of various bacterial diseases offish. The present study examines the pharmacokinetics and bioavailability of sulfamonomethoxine in Japanese ell Anguillajaponica that is the most popular cultured fish in Japan. The pharmacokinetics of sulfamonomethoxinewere determined after intravascular (i.v.), 200 mg/kg body weight, and oral (p.o.), 400 mg/kg body weight, administration. The consentration of sulfamonomethoxinewas determined by our high-performance liquid chromatographic method. Serum levels of i.v. could be fitted to a two-compartment model and those of p.o. to a onecompartment model. The area under the serum concentration time curve (AUC) was 59, 100 and 28, 400μg·h/ml for i.v. and p.o., respectively. The bioavailability of sulfamonomethoxine was found to be 24.0%. The acetylation of the drug for i.v. was 3.1%.
