Abstract
The absorption and excretion of chloramphenicol (CP)of the cultured yellowtail were studied. The water temperature during the experiment was about 22°C. The average body weight of the cultured yellowtail used in the experiment in which 50 mg.CP/Kg was administered was 307.2 grams and 370 grams in case of 100 mg. CP/Kg. The results obtained are summarized as follows.
1) When dose of 50 mg. CP/Kg was administered orally once to the yellowtails, the blood level of CP reached a maximum of 8.6μg/ml after 8 hours, maintainning a level of 3.1μg/ml even after 48 hours.The spleen level of CP reached a maximum of 20.1μg/g after 4 hours, maintainning a level of 8.6μg/g even after 48 hours. The kidney levels of CP showed the peak of 16.2μg/g after 8 hours. The liver levels of CP showed the peak of 14.1μg/g after 4 hours. The muscle levels of CP showed the peak of 5.4μg/g after 8 hours. The levels of CP in those three tissues became almost undetectable after 48 hours.
2) When 100mg. CP/Kg was administered once orally in the yellowtails, the blood, spleen, kidney, liver and muscle levels of CP were about twice as high as those in case of 50mg. CP/Kg.
