Hereditary Pheochromocytoma/Paraganglioma Syndrome : An Overview

Abstract

Recently, genes encoding the succinate dehydrogenase subunit have been identified as the genes responsible for hereditary pheochromocytoma. Subsequent studies have demonstrated that pheochromocytoma/paraganglioma due to germline mutations of those genes are much more frequent than previously expected; a novel clinical entity “hereditary pheocyromocytoma/paraganglioma syndrome（HPPS）” has been established. A clinical and genetic study of Japanese HPPS patients has been initiated the fubdubgs are expected to facilitate better