Importance and Complexity of Establishing Diagnostic Guideline for the Lynch syndrome

Abstract

Diagnosis, treatment, and molecular mechanism of Lynch syndrome have been advanced by the development of ICG-HNPCC by InSiGHT. Although germline mutation of mismatch repair genes hasbeen identified as playing a causative role in Lynch syndrome, Lynch syndrome is still the subject of investigation, However, it is difficult to accumulate evidence by prospective randomized studies because of the nature of this syndrome. However, a Japanese version of the guidelines for treatment of Lynch syndrome is required by general clinicians, and the significance and difficultes establishing such guidelines are discussed.