Abstract
BRCA1 and BRCA2 are genes associated with Hereditary Breast and Ovarian Cancer （HBOC）, and women with a mutation of them have life-time risks of 50~80% of breast cancer and 10~40% of ovarian cancer. We examined 7 patients who developed ovarian cancer or peritoneal cancer following the diagnosis of breast cancer and considered the surveillance for case of suspected HBOC. The time between the diagnoses of breast cancer and ovarian, peritoneal or tubal cancer was 4 to 14 years. 5 patients were diagnosed with stage Ⅲc ovarian cancer and 2 with stage Ⅳ and all cases were advanced at the time of diagnosis. While ovarian or peritoneal cancer was detected in 2 patients by follow-up CT images without subjective symptoms , 5 patients had abdominal symptoms at diagnosis. It appeared that the early detection of ovarian and peritoneal cancer was difficult for cases of suspected HBOC with imaging examination such as CT-scan only. Since the time between the diagnosis of breast cancer and the development of ovarian and peritoneal cancer was long, it is supposed to be useful to re-obtain detailed family history in order to recognize high-risk patients and family members.
