Clinical Experience of Treatment in Patients with Familial Adenomatous Polyposis Associated with Distant Metastatic Colorectal Cancer

Abstract

Purpose: This study evaluated the outcome of treatment for FAP patients with distant metastatic colorectal cancer. Patients and methods: The subjects were 6 classic FAP patients with distant metastatic colorectal cancer, who underwent （procto-） colectomy as the first surgical intervention for FAP in our institution between September 2000 and March 2014. Patient background data, including types of treatment and their outcomes were retrospectively examined. Results: Ileal pouch anal anastomosis（ IPAA） was performed in one patient, colectomy with ileorectal anastomoses（IRA）was performed in 4 patients, and partial colectomy（Hartmann’s operation）was performed in one patient with perforated rectal cancer. Four patients underwent additional curable metastatectomy and two patients had unresctable liver metastasis. Each patient received oxaliplatin-based chemotherapy pre- or post-operatively. The overall 3-year survival rate was 66.7%. Conclusion: These results suggest that IPAA or IRA in combination with metastatectomy might contribute to prolongation of survival time for the patients with distant metastatic colorectal cancer in the era of modern chemotherapy.