Screening Strategy for Lynch Syndrome in Endometrial Cancer

Abstract

Lynch syndrome（LS）is an autosomal-dominant inherited disorder mainly due to a predisposing germline mutation in the DNA mismatch repair （MMR） genes and is associated with increased risk for LS-associated cancers, particularly colorectal cancer and endometrial cancer（EC）. LS identification in EC is significant for prediction and prevention of subsequent other associated cancers, but suitable methods for it have not been established. Here, we explain about the LS screening strategy in EC and our study results. The screening procedures consisting of highly sensitive clinical criteria and additional molecular analyses would be a strategy that improves the LS identification efficiency and reduces its cost.