Two cases report of RRSO and RRM for BRCA1 gene mutation in the same family tree

Abstract

We conducted a preventive surgery to reduce cancer risk for 2 cases with an identical BRCA1 gene mutation (NM_007294.3: c.3397_3398delTT). Both cases were 42 years old at the time of the preventive surgery, performed after repeated genetic counseling in consideration of childbirth hope and age to give birth. There was no occult cancer pathologically in either case, and both are still under surveillance and no evidence for the onset of cancer. In this study, we focus on the contents of genetic counseling conducted for the cases.