HNPCC and Endometrial Cancer

Abstract

Hereditary nonpolyposis colorectal cancer（HNPCC） is a familial cancer of the autosomal dominant inheritance form. Since complications of endometrial cancers develop at a high frequency in HNPCC patients, it has become known that part of endometrial cancers are HNPCC-related familial cancers. It has also been suggested that ovarian cancers and breast cancers, in addition to endometrial cancers, are related to HNPCC. HNPCC-associated endometrial cancers appear to have unique characteristics biologically and clinico- pathologically, but the exact nature is unknown. There is an urgent need for gynecologists to undertake a nationwide analysis with correct knowledge and detailed research about family history.