JOURNAL OF FAMILIAL TUMORS
Online ISSN : 2189-6674
Print ISSN : 1346-1052
Genetic Instability and Inactivation of Mismatch Repair Proteins in Synchronous Multiple Colorectal Cancers
Takashi NishigamiKazuo TamuraHiroko SashioNaohisa TakedaKen SagayamaAkira OkimuraHiroshi HiranoKeiji NakashoTakehira YamamuraJoji UtsunomiyaKunio Uematsu
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JOURNALS OPEN ACCESS

2003 Volume 3 Issue 2 Pages 79-84

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Abstract

To find fresh mutations in HNPCC cases, synchronous multiple colorectal cancers were examined. We selected thirty-one lesions in 19 cases of synchronous multiple colorectal cancers. Findings of MSI-High were detected in 6 of the 19 cases (31.6%)and 11 of the 31 lesions(35.5%). The MSI-positive findings(MSI-H or MSI-L) were detected in 16 of the 19 cases(84.2%) and 26 of the 31 lesions(83.9%). Fifteen of the 31 lesions(48.4%)showed negative stainings for MLH1 and/or MSH2 antigen, using immunhistochemical methods. Nine of the 11 lesions(81.8%)indeed showed negative immunostaining for MLH1 and/or MSH2 antigen. The results of the MSI status and expression of MLH1 and MSH2 agreed between different plural tumors in the same case. Moreover, the correlation between MSI-High and inactivation of MLH1 and MSH2 was recognized. These results suggest that MSI and immunohistochemical studies with antibodies of MLH1 and MSH2 are useful methods to find new HNPCC-patients who are not consistent with the criteria for HNPCC.

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© 2003 The Japanese Society for Familial Tumors
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