Abstract
Human hereditary kidney cancers are classified into 6 diseases, such as von Hippel-Lindau（VHL）disease, Hereditary papillary renal cell carcinoma, Hereditary leiomyoma renal cell carcinoma Birt-Hogg-Dube syndrome, and Hereditary paraganglioma and renal cell carcinoma. Here we briefly describe the details of these 6 diseases. Mutation is usually not detected in sporadic RCC except VHL disease. In the case of VHL disease, family alliances have been organized by patients in the US, Japan or other countries. Several social activities are carried out by the VHL family world-wide. These activities are becoming more influential throughout society. We also describe the social activities carried out by the VHL Family Alliance in Japan and in other countries.
