2016 Volume 31 Issue 3 Pages 346-353
Candida glabrata as an oral candidiasis pathogen is a growing concern with increasing prevalence rates and its reduced susceptibility to azoles. We assessed the prevalence rates of Candida species among oral candidiasis in gerodontology outpatients of Hokkaido University Hospital.
We examined oral mycological flora of 156 patients, from August 2013 to December 2015, in whom culture tests from tongue dorsa were positive. Candida glabrata isolated concomitantly with Candida albicans were designated as a mixed group, and Candida albicans alone as a single group. Background variables and susceptibility to antifungal agents were compared between the two groups by statistical analysis.
The single group was isolated from 84（54%）and the mixed group from 36（23%）of patients. There were many other species of Candida without C. albicans, unlike in previous reports. A number of C. glabrata were not isolated as a single species but found in combination with C. albicans. Regarding background variables and susceptibility to antifungal agents, the mixed group was significantly more prevalent in patients with dentures and showed higher resistance to antifungal drugs than the single group.
Our results indicate that C. albicans and C. glabrata concomitant infection of oral candidiasis is strongly associated with the wearing of dentures and higher resistance to antifungal drugs.
