Abstract
Helicobacter pylori (H. pylori) infection is the primary cause of atrophic gastritis, which is a major risk factor for the development of gastric cancer. This study aimed to reveal the relationship between atrophic gastritis and lifestyle factors. Data for analysis were obtained from a baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in the Kyoto area. Eligible subjects were individuals who were 35 to 69 years old and who participated in a self-administered questionnaire survey including lifestyle factors and in a health check-up between 2011 and 2012. The inclusion criteria of this study were as follows: those who had no history of upper gastrointestinal surgery, upper gastrointestinal disease treatment, and renal failure. Of the 1,894 individuals who participated in the J-MICC Study in Kyoto during the study period, 1,280 (67.6%) were included in this analysis (419 men and 861 women). Atrophic gastritis was diagnosed by the pepsinogen (PG) test method: serum PG I level (≤70ng/ml) and PG I / PG II ratio (≤3.0). The presence of immunoglobulin G antibodies to H. pylori indicated H. pylori infection. After adjusting for age, H. pylori infection, smoking status, and alcohol consumption, the odds ratio of atrophic gastritis associated with beef and/or pork intake 3 times a week or more frequently was 2.22 in men [95% confidence interval (CI) 1.07 - 4.58]. In women, the odds ratio of atrophic gastritis associated with passive smoking within a year was 2.03 (95% CI 1.02 - 4.03). In conclusion, the results of this study in a Japanese population show a positive association between atrophic gastritis and beef and/or pork intake more than 3 times a week (in men) and passive smoking within a year (in women).
