Study on background data in non-alcoholic fatty liver diseases comparing with normal and abnormal liver function tests groups.

Abstract

In recent years, fatty liver has not been considered to be a benign disease, but a progressive disease. We aimed to determine the clinical significance of end-stage fatty liver through an investigation of contributing factors. NAFLD patients were divided into normals (400 cases) and abnormals (288 cases) based on liver function results. For the abnormal group, a univariate analysis revealed that they were young, predominantly male, had significantly high BMI, systolic blood pressure, fasting blood glucose level and HbA1c. A multivariate analysis revealed that being male and young, and having a high fasting blood glucose level were significant risk factors. In a comparison between males and females, a multivariate analysis revealed that for males, being young, having a high BMI and fasting blood glucose level were significant risk factors, whereas for females, only high systolic blood pressure was considered to be a significant risk. The results suggest that liver impairment in NAFLD patients is not related to the ageing process, and that for females other factors may be involved.