2022 Volume 40 Issue 3 Pages 195-201
There are few reports of uterine cervical neuroendocrine carcinoma (NEC) during pregnancy, and there are no definite treatment guidelines. We experienced a case of NEC diagnosed at 21 weeks' gestation. The patient was a 29-year-old female who had one child. A 20 mm polypoid mass was found in her cervix at 21 weeks' gestation. Histopathology confirmed NEC, and the tumor was 15 mm in diameter and diagnosed as cervical cancer stage IB1. Since the tumor diameter was less than 20 mm and no lymph node metastasis was observed, we decided to wait until 26 weeks' gestation. However, on the second day of the 24th week of gestation, the tumor rapidly grew, and an emergency cesarean section and radical hysterectomy were performed. The baby weighed 577 g and was growing well. Pathological examination revealed small-cell NEC with closed lymph node metastasis (pT1b2N1M0). Four cycles of postoperative PE therapy were administered, but pelvic recurrence and liver metastasis occurred within five months, and the patient died 10 months after surgery. Since uterine cervical NEC generally progress rapidly, when diagnosed during pregnancy, careful consideration of the gestation period and impact on the fetus is necessary for decision-making.
