2024 Volume 42 Issue 1 Pages 16-21
Synopsis: Recurrence of carcinoma in situ (CIS) of uterine cervix in the form of invasive cancer is extremely rare. We report a case of repeated recurrence after total hysterectomy for CIS. The patient underwent cervical conization for CIS at 48-years-old. At 57-years-old, the patient had a recurrence of CIS and underwent extended hysterectomy. At 59-years-old, the patient had an abnormal vaginal stump cytological diagnosis and the histological diagnosis was CIS. The patient was referred to our hospital because a recurrent tumor was found on the vaginal stump. A recurrent lesion was found on the vaginal wall and a 2 cm-sized tumor was palpated on the left side of the vaginal stump. The vaginal wall histology showed SCC and the lesion disappeared after CCRT. 9 months after, a recurrence was found in the vaginal stump, and radiotherapy was performed again, but 4 months later, a recurrence in the vaginal stump and metastasis in the external iliac lymph node were found and chemotherapy was performed. 3 months later, a recurrence in the external iliac and obturator lymph node was found, and the patient underwent resection of the recurrent tumor and pelvic lymph node dissection. 15 months after surgery, the patient underwent resection of recurrent tumor and vagina and colostomy. 17 months after surgery, para-aortic lymph node metastasis was detected and radiotherapy was administered. She has had recurrences and repeated chemotherapy since then and is still undergoing chemotherapy.
