2024 Volume 42 Issue 3 Pages 256-262
Synopsis: Mesonephric-like adenocarcinoma (MLA) is a rare tumor of the uterine corpus and ovaries. It is difficult to obtain a true diagnosis because MLAs have several configurations. We report a case of MLA of the uterine corpus, implying divergence from endometrioid adenocarcinoma, including morphological and immunohistochemical considerations.Key words: uterine corpus, mesonephric-like adenocarcinoma, case report
Case: A 71-year-old woman (gravida 6, para 1) presented with heavy genital bleeding and was admitted to our hospital. Examination revealed a suspected carcinoma measuring 45 mm × 35 mm in the uterine cavity. Endometrial cytology revealed an endometrioid carcinoma. She was diagnosed with stage IA uterine corpus carcinoma (Stage IA) and underwent a total laparoscopic hysterectomy and bilateral salpingo-oophorectomy. A pathological examination revealed several atypical cell configurations. Staining for TTF1, GATA3, and CD10 was positive; staining for ER was focally positive; and staining for PR was negative. The partial area implies that the MLA originated from endometrioid carcinoma because the MLA and endometrioid carcinoma were consecutive.
Conclusion: MLA is a rare tumor, and its origin remains unknown. The accumulation of more information and further reports is required.
