2026 Volume 44 Issue 1 Pages 7-17
Synopsis: Ovarian immature teratomas are malignancies that contain immature tissue resembling the embryonic components. Rarely, metastatic implantation composed of only mature glial cells within the peritoneum is seen and is termed peritoneal gliomatosis. Peritoneal gliomatosis corresponds to Grade 0 and the prognosis is favorable. In addition, although extremely rare, lymph node metastases composed entirely of mature glial tissue may be seen in immature teratomas. This condition is called nodal gliomatosis, and there are very few cases of this disease in the world. We report a case of simultaneous nodal gliomatosis and peritoneal gliomatosis with an immature teratoma. The patient was a 31 year-old woman and was suspected to have immature teratoma and right cardiac diaphragmatic lymph node metastasis on preoperative imaging diagnosis. The patient underwent laparotomy with left adnexectomy, omentectomy, and peritoneal stripping of the Douglas fossa. Histopathology revealed a Grade 2 immature teratoma and peritoneal gliomatosis. Postoperatively, bleomycin, etoposide, cisplatin therapy was administered, but the enlarged right cardiac diaphragmatic lymph node remained and was removed by thoracoscopic surgery. The pathology showed only mature glial cells and the diagnosis of nodal gliomatosis was made. This may be the first case of nodal gliomatosis found in the thoracic cavity.Key words: ovary, immature teratoma, nodal gliomatosis, peritoneal gliomatosis
