Abstract
During cancer treatment, cryopreservation of oocytes is sometimes performed before administering chemotherapy or radiation therapy, which may affect fertility. In general, controlled ovarian stimulation (COS) is required to collect oocytes; however, ovarian hyperstimulation syndrome(OHSS) may occur in patients with polycystic ovary syndrome (PCOS), which is associated with an increased risk of OHSS. We report a case of a breast cancer patient with PCOS who requested cryopreservation and underwent laparoscopic ovarian drilling (LOD). The patient was 34 years old female with no previous history of pregnancy. Since menarche, she experienced irregular menstrual cycles; after a medical workup, she was diagnosed as PCOS. Four months after her marriage, she was diagnosed with breast cancer in the left breast. Radiation therapy was administered after the patient underwent a partial mastectomy and before administration of chemotherapy. During this Radiation period after mastectomy, about one-and-a-half months , the patient underwent LOD for the treatment of PCOS; we also collected five immature oocytes from the puncture fluid for cryopreservation. Radiation therapy was interrupted for only one day to perform the LOD with reduced port surgery (RPS). After LOD, the patient underwent COS; two mature oocytes were harvested and frozen.
Although our institution did not perform assisted reproductive technology (ART), we were able to cryopreserve oocytes from the punctured fluid; this was accomplished by collaborating with an institution that specialized in ART. Simultaneous collection of oocytes during LOD is useful for ART including in vitro fertilization (IVF). In addition, the current trend toward reduced port surgery (RPS) can shorten the length of hospital stay. Thus, it is expected that the implementation of LOD will expand in the future.
