Risk Factor Analysis for Drug-Induced Kidney Injury Resulting from Short-Term Vancomycin Therapy in Elderly Patients

Abstract

Aim: Short-term use of vancomycin may cause kidney injury in elderly patients. We analyzed the risk factors for kidney injury in elderly patients who received vancomycin temporarily.

Methods: We investigated 98 vancomycin-treated (<15 days) elderly patients (≥ 75 years). The treatment caused kidney injury in 13 patients. A multivariate logistic regression analysis identified the risk factors for kidney injury.

Results: The statistical analysis identified three independent risk factors as combined precursors of kidney injury: use of non-steroidal anti-inflammatory drugs (OR: 43.1, 95% CI: 3.9-474.0), elevated trough concentration (OR: 55.2, 95% CI: 3.7-826.0), and a total combination of ≥ 9 drugs (OR: 6.8, 95% CI: 1.2-38.8).

Conclusion: Usage of non-steroidal anti-inflammatory drugs, ≥ 9 drugs in combination, and an elevated trough concentration may induce kidney injury in elderly patients who receive vancomycin temporarily.