Study of Evaluation on Risk Factor of Cerebrovascular Disease-Analysis of Stroke Registration in Tochigi Pref ecture-

Abstract

A survey study on the incidence of stroke was carried out in Tochigi prefecture from October 1988 to September 1990. 2, 337 cases of stroke were registered during one year and 2, 006 cases were first patients. We studied the risk factor of stroke from 398 paired data using 3 methods: 1) McNemar's paired match analysis, 2) Hayashi's quantification II analysis, which is one of the multivariate analysis methods and 3) dose-response analysis. In order to omit confusing factors, the data were stratified by the following classes; sex, age, district and stroke type. The data were analyzed from two viewpoints. One of the viewpoints was primary prevention of stroke according to life style and family history. The other was secondary prevention of stroke from clinical findings and subjective symptoms. From the viewpoint of primary prevention of stroke, the risk factors were; physical activity, family history such as stroke and hypertension, lack of soybean intake and intake of alcohol. Cerebral infarction was affected by smoking in dose-response. Alcohol intake dose-response appeared in males more than females, it affected the 50-59 age group more than the under 50 and over 59 age groups. It increased the risk factor of cerebral hemorrhage more than cerebral infarction or subarachnoidal hemorrhage. From the viewpoint of secondary prevention of stroke, one of the risk factors was anamnesis of hypertension. Cerebral hemorrhage was related to maximum high blood pressure and cerebral infarction was significantly connected with serum total cholesterol level in dose-response analysis.