Abstract
This study investigated the characteristics of recipients received medical check-ups and factors associated with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT) using cross-sectional and follow-up studies. In 1992 and 2000, 1, 112 and 849 subjects (aged 22-79 years), respectively, received check-ups at a private hospital in suburban Tokyo and participated in a cross-sectional study. The follow-up study consisted of 210 subjects who had been examined in both 1992 and 2000. The prevalences were NGT 76.4%, IFG 2.0%, IGT 15.3%, T2DM 6.3% in 1992, and 68.4%, 3.4%, 18.7%, 9.5% in 2000, respectively . Subjects in 2000 showed significantly higher mean age and BMI than those in 1992. In the follow-up study, 77.1% of NGT subjects in 1992 maintained the same status (NGT-NGT group), 16.3% progressed to a borderline-type blood glucose status (NGT-Border group), and 6.6% developed T2DM in 2000. Of 37 subjects with borderline-type in 1992, 67.6% of them maintained the borderline status in 2000. On comparison of the NGT-NGT and NGT-Border groups, elevated GGT and UA in 1992 were associated with the development of IFG/IGT status in 2000. In addition, there were significant interaction effects of time and blood glucose status in SBP, AST, GGT, and TG. In conclusion, it was suggested that GGT and UA might be predictors for conversion to borderline-type blood glucose status.
