A STUDY OF RISK FACTORS FOR ANTIBIOTIC SELECTIVE PRESSURE IN CARBAPENEM-TREATED PATIENTS

Abstract

To study the risk factors for antibiotic selective pressure in carbapenem-treated patients, we analyzed the data for inpatients at Showa University Hospital, Tokyo, Japan. We performed univariate and multivariate analysis of two risk factors: patient background information and amount of antibiotic used in carbapenem-treatment patients with or without carbapenem-resistant organisms. Multiple logistic regression analysis was performed for factors with P < 0.20 in the univariate analysis. Multivariate analysis showed significant differences with three variables: age > 70 years, hospital inpatient days, and hemodialysis. These results suggest that appropriate antibiotic use and infection control are important for the management of antibiotic-resistant organisms in carbapenem-treated patients. In addition, there was no significant difference between the antibiotic quantitative factors and carbapenem-resistant organism detection. Therefore, when evaluating the correlation between detection of antibiotic-resistant bacteria and usage of antibiotics in hospitals, it is necessary to pay attention to the interpretation of results.