Abstract
Non-steroidal anti-inflammatory drugs （NSAIDs） are known to cause premature ductus arteriosus closure. In recent years, polyphenols have been reported to exert the same effect. Herein, we present a case of premature ductus arteriosus closure probably caused by polyphenols from azuki bean tea and rooibos tea. The patient was a newborn boy, who demonstrated poor oxygenation （SpO2 87％） 2 h after birth; therefore, oxygen administration was initiated. Owing to continued oxygen demand beyond 24 h of age, the patient was admitted to a neonatal intensive care unit. Chest X-ray revealed right ventricular hypertrophy, and a 12-lead electrocardiogram demonstrated pulmonary P waves, right-axis deviation, and strain pattern. Echocardiography revealed a flattened ventricular septum in the short-axis image, with no ductus arteriosus. Ductus arteriosus obstruction was thus suspected to cause elevated right ventricular pressure and hypertrophy. A medical interview revealed that the patient had not taken NSAIDs during pregnancy but had been drinking adzuki-bean tea and rooibos tea daily. Polyphenols contained in adzuki-bean tea and rooibos tea were, therefore, suspected to cause the symptoms. Polyphenols are generally considered to promote good health; however, their consumption should be limited during pregnancy.
