Applications of Supercritical Crystallization Techniques to Pharmaceutical Materials Processing

Abstract

Supercritical crystallization techniques have advanced in recent years with increasing applications covering a wide variety of chemical processes. Pharmaceutical materials processing with supercritical crystallizations is a relatively new and efficient approach to prepare high purity and micron-sized particles. In this article, the solubility characteristics of organic compounds in supercritical fluids and the applications of the supercritical crystallization techniques to pharmaceutical materials processing are reviewed.