Abstract
There have been innovative high-pressure studies on biological processes applying modern techniques of genetics and molecular biology in model microorganisms such as bacterium Escherichia coli and yeast Saccharomyces cerevisiae. Recent advanced investigations in this field have been systematically done in the genome-wide level to identify genes and proteins required for microbial growth and survival under high hydrostatic pressure. This article is an overview of studies on the effect of high pressure on microbial physiology and the challenges in piezophysiology, which has been proposed to discover whether the responses of living cells to high pressure are relevant to their growth and viability.
